The solution was cooled slowly to room temperature, then transferred to an ice-water bath. As seen in Figure 4, the general mechanism for catalyzation by an acidic species such as boron trifluoride or sulfuric acid involves the protonation of the electrophile, increasing its electrophilicity. H 2 SO 4 (use a dropper, H 2 SO 4 is highly corrosive) and swirl the flask gently until the salicylic acid dissolves. 0000002776 00000 n
Synthesis of Aspirin - Lab Report and Analysis - Odinity Analysis of Aspirin. 0000003728 00000 n
The methods used included recrystallization and scratching to produce a precipitate, which was then filtered to remove any excess moisture. Add 5 mL (0.05 mole) of acetic anhydride, followed by 5 drops of conc. Some test tubes contained polymerized product that was not added to the flask.
German chemist Felix Hoffmann synthesized what would become known as Preparation of Aspirin Lab Report. Iron (III) chloride can be coordinated and then reduced by deprotonated phenol. Synthesis of Aspirin Lab Report. Place approximately 200 mL of water into a 400 mL beaker and allow to warm to 70°C on a hot plate Further Analysis When was aspirin first synthesized, by whom, and for what purpose? Enthalpies of other side reactions, such as the polymerization of salicylic acid may have also contributed to the temperature change, corrupting the data. You will determine the percent yield of aspirin and you will confirm it's identity with FT-IR spectroscopic anaylsis. Synthesis of Aspirin Lab Report 2989 Words | 12 Pages. The ielts general training… Synthesis of Aspirin Synthesis Purification Characterization. Summary: In this experiment, we produced 4.21 g of acetylsalicylic acid. Place approximately 200 mL of water into a 400 mL beaker and allow to warm to 70°C on a hot plate Further Analysis When was aspirin first synthesized, by whom, and for what purpose? Aspirin is an ester that has high molecular weight and it not soluble in water hence the solid can be separated by crystallization process. Aspirin has a long past. The procedure was repeated using one drop of molecular iodine solution in place of iron (III) chloride solution. ; Heat the flask gently on the steam bath for at least 10 minutes. During the lab aspirin was synthesized, purified, and analyzed. PROCEDURE. Aspirin Synthesis and Analysis. Our theoretical yield was calculated to be 5.22 g. The mechanism for this synthesis provides examples of three major classes of chemical reactions: hydrolysis, condensation, and proton transfer. Synthesis of Aspirin Synthesis Purification Characterization. German chemist Felix Hoffmann synthesized what would become known as Our theoretical yield was calculated to be 5.22 g. Read other papers done by Harper: Social Studies, Chapter 3, Mesopotamia; 77118650533_Corporate_Social_Responsibility_vUr08tHyktmI SYNTHESIS OF ASPIRIN Pre-Lab Assignment Study the sections related to stoichiometry and limiting reactant in your textbook. Synthesis of Aspirin - Lab Report and Analysis - Odinity 1. Am. An ester is a compound that is formed when an acid reacts with an alcohol, -OH group. It is the two-step synthesis of aspirin starting from oil of wintergreen. 2.000 grams of salicylic acid were placed into an Erlenmeyer flask. A small mass of one of four different unknown solid compounds was added to each tube. The results displayed a percent yield of 34.3%, from a theoretical yield of about 1.97g of aspirin and an actual yield of approximately 0.68g of aspirin. ; Heat the flask gently on the steam bath for at least 10 minutes. trailer
This chart was upload at October 12, 2020 upload by Admin in Lab Report Sample.. Synthesis Of Aspirin - Aspirin Synthesis Lab Report - The Laboratory Report is one of the numerous resources offered to you on the Internet for a variety of education details associated to your laboratory work. Upon completion of the lab, analysis, and calculations, it is evident that the synthesis of aspirin is possible using these methods but that the yield will be relatively low. Simultaneously, the START button of an Apple iPhone 4 stopwatch application was pressed. Upon completion of the lab, analysis, and calculations, it is evident that t… Aspirin alters the oxygenase activity of prostaglandin synthetase by moving the acetyl group to a terminal amine group4. Pyridine also activates the electrophile by reacting with acetic anhydride to form the N-acyliminium ion, as seen in Figure 3. Iodide ions infiltrate the helical chain of long starch molecules, turning the solution dark purple/black in the presence of amylose2. Write The Balanced Equation For This Reaction Showing The Structures Of The Reactants And Products. Soc. Personal and Average times for reaction solution to increase by 4 ˚C. Write The Balanced Equation For This Reaction Showing The Structures Of The Reactants And Products. In this experiment, aspirin will be synthesized by reacting acetic. The test tubes were placed in the previously prepared hot water bath for 7 minutes with occasional stirring. The results displayed a percent yield of 34.3%, from a theoretical yield of about 1.97g of aspirin and an actual yield of approximately 0.68g of aspirin. Organic chemistry I lab report. 0000002154 00000 n
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Reactions: Procedure and Results: Aspirin Synthesis Tap water was heated on a steam bath in a 250 mL beaker. • Take a small amount of the aspirin tablet and dissolve as much as you can in 3 drops of ethyl acetate. One of the compounds used in the synthesis of aspirin is salicylic acid, which is itself a pain reliever that was known to many ancient cultures, including the Native Americans who extracted it from willow tree bark. Members of the class may have also utilized different techniques to measure the time taken for a 4 ˚C temperature change to occur. In the reaction the hydroxyl group on the benzene ring in salicylic acid reacted with acetic anhydride to form an ester functional group. After the times required for a 4 ˚C temperature increase in each reaction solution had been recorded, the reaction vessels were allowed to sit, with occasional stirring, for a few additional minutes to ensure that each reaction reached completion. Aspirin’s chemical name is acetylsalicyl-ic acid, and it is synthesized from the reaction of acetic anhydride with salicylic acid in the presence of phosphoric acid as a catalyst. The personal times measured for the rise in temperature are relatively accurate in relation to the class average results, as the recorded times fall within one standard deviation of the mean. One drop of 1% iron (III) chloride solution was added to each tube and color changes were noted and recorded. A small melting point range close to the standard of acetylsalicylic acid would suggest a high purity sample, meaning the recrystallization process was effective. It is carried out to form ester from an acid and an alcohol. Salicylic acid and acetic anhydride have heats of solvation in water, so aqueous catalyst would change the reaction’s rate of temperature change relative to the non-aqueous catalyst even if the catalysts were equally effective. The sample should have been slowly cooled to 0 ˚C by placing it in a refrigerator and slowly lowering the temperature. IUPAC NAME: 2-acetoxybenzoic acid Lower absorbance values would indicate that a greater concentration of phenol was present and the absorbance value could be used to directly determine the concentration, 1 Cappelli, G. J. Chem. Reactions: Procedure and Results: Aspirin Synthesis Tap water was heated on a steam bath in a 250 mL beaker. 1616 0 obj <>
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Because almost no yield was obtained, the remainder of the experiment was carried out using another classmate’s (Patrick Semesky’s) crude acetylsalicylic acid product. The goal of this experiment was to synthesize aspirin. Part 3: Preparation and Standardization of HCl Procedure Part 4: Quantitative Analysis of Aspirin Further Analysis Conclusion The overall objectives of This product will be impure because of unreacted salicylic acid and visible spectroscopy can help determine the percentage of the impurity of the product. Rasan Cherala Synthesis of Aspirin lab Purpose: The purpose of this experiment is to create aspirin by reacting salicylic acid with acetic anhydride. An ester is a compound that is formed when an acid reacts with an alcohol, -OH group. It is the acetyl derivative of salicylic acid and is an example of a salicylate drug. After synthesis and analysis, it will be deter-mined if the crude and recrystallized samples were composed solely of either salicylic acid, acetylsalicylic acid, or a combination of both (3). This is a relatively high yield and any error can be accounted for by the incomplete reaction of the reactions, side reactions, or loss molecules through poor recrystallization, spills, or solution left in beakers, etc. a. The purpose of this experiment is to synthesize the common pain killer aspirin via an esterification reaction between Salicylic Acid and Acetic Anhydride in the presence of concentrated sulfuric acid acting as a catalyst. Part 3: Preparation and Standardization of HCl Procedure Part 4: Quantitative Analysis of Aspirin Further Analysis Conclusion The overall objectives of ���yµB�B]:M\�e��&pp0$x����#�����.�a����#3# ����#�z�����a��. The intensity of the purple color corresponds with the concentration of phenol functional groups present. 1629 0 obj<>stream
Synthesis Of Aspirin Formal Lab Report. 5 mL of distilled water is added to test tube A. Background: Aspirin is one the best known and most widely used medicines in modern society. Synthesis of Aspirin … The purpose of this experiment is to synthesize the common pain killer aspirin via an esterification reaction between Salicylic Acid and Acetic Anhydride in the presence of concentrated sulfuric acid acting as a catalyst. The reaction solution was stirred with a thermometer for a few seconds to ensure that all reagents and the cataylst had appropriate molecular interface. The Synthesis of Aspirin 1. Synthesis and Spectral Analysis of Aspirin By: Nikki Goeddeke Lab Partner: Casey Goettel March 19, 2015 Organic Chemistry II Section 21 Introduction Purpose The purpose of this experiment is to synthesize and analyze aspirin by the esterification of salicylic acid to aspirin using acetic anhydride. Antipyretic (fever reducer)! This would reduce yield and shift equilibrium toward the reverse reaction. Salicylic acid (1.00 g + 0.005 g) and acetic anhydride (2.0 mL + 0.05 mL) were added to each of four test tubes. A large melting point range would suggest an impure sample and ineffective recrystallization process. Rundle, J. F. Foster, R. R. Baldwin. This reaction is represented visually below: Figure 1.1 Aspirin synthesis: chemical reaction involving salicylic acid and acetic anhydride as reactants and aspirin and acetic acid as products. Immediately plunging the hot ether solution into an ice bath would precipitate large, impure crystals. This is done through utilization of the processes of esterification between an alcohol and an acid. In this experiment, you will prepare aspirin from salicylic acid and acetic anhydride using sulfuric acid as a catalyst. The Synthesis and Analysis of Aspirin. Exothermic side reactions would increase the reaction temperature more quickly even if the salicylic acid acetylation rate had not changed. .. 5/full-report-synthesis-of-aspirin.html (accessed. The synthesis of aspirin is an organic chemistry experiment in many specifications for students of ages 16-18 years. 0000000016 00000 n
x�b```b``�b`�u �����hf`4vTf�V!��Yŵ�� W��^� Add 5 mL (0.05 mole) of acetic anhydride, followed by 5 drops of conc. Procedure: Week One: In order to synthesize aspirin, acetic acid was reacted with salicylic acid. Synthesis Of Aspirin – Aspirin Synthesis Lab Report is free lab report sample. 1616 14
SYNTHESIS OF ASPIRIN (acetylsalicylic acid) Place 2.0 g (0.015 mole) of salicylic acid in a 125-mL Erlenmeyer flask. She studies at the University of California, Santa Barbara. Indus. Upon completion of the lab, analysis, and calculations, it is evident that the synthesis of aspirin is possible using these methods but that the yield will be … Synthesis Of Aspirin Lab Report. Vacuum filtration through a Hirsch funnel was employed to collect the crude product of acetylsalicylic acid crystals. The flask was heated for 5 minutes over a steam bath to hydrolyze excess acetic anhydride then rapidly cooled in an ice bath. The main purpose of this lab is to allow students to have the opportunity to observe the synthesis of various organic compounds, namely aspirin and the oil of wintergreen. The partner’s yield, as seen in Table 2, was 59.0 %. Though the general mechanism uses a Bronsted acid as the catalyst, the mechanism is analogous with a Lewis acid (such as BF3), though instead of a proton, the oxo group will be coordinated by a different electron deficient center (such as the unfilled p orbital of a boron atom). Figure 1: Reaction of Aspirin (Snelling, 2013) MATERIALS AND METHODS Goggles Gloves Lab coat Salicylic Acid 50 mL Erlenmeyer Flask Endothermic side reactions would retard the rate of temperature increase. To test for the presence of starch, iodine solution was added. Lab Report Synthesis and Characterization of Aspirin (Acetylsalicylic Acid) The Synthesis and Characterization of Aspirin (Acetylsalicylic Acid). The purity of the sample will be qualitatively determined with melting point analysis. The Synthesis and Analysis of Aspirin. Label three test tubes; place a few crystals of salicylic acid into test tube #1, a small sample of your aspirin into test tube #2, and a small sample of crushed Page 3/15 Summary: In this experiment, we produced 4.21 g of acetylsalicylic acid. SYNTHESIS OF ASPIRIN (acetylsalicylic acid) Place 2.0 g (0.015 mole) of salicylic acid in a 125-mL Erlenmeyer flask. Table 1. The theoretical yield of 5.22 g acetylsalicylic acid was stoichiometrically determined using the starting mass of salicylic acid (4.0 g) because it was the limiting reactant. 0000003774 00000 n
In this experiment aspirin, also known as acetylsalicylic acid, was synthesized from salicylic acid and acetic anhydride. Synthesis and analysis of aspirin formal lab report >>> click to order essay Essay on sleeping beauty Category: essays research papers title: the relationship between snowball and napoleon in animal farm. Phosphoric acid is added to catalyze the reaction. Synthesis of Aspirin Lab Report - essay example for free Newyorkessays - database with more than 65000 college essays for studying 】 Aspirin Synthesis Lab Part 1: The Synthesis of Aspirin Procedure Steps 3 - 5 were repeated twice more for two more titrations. The sodium acetate experiment is the trial that all members of the class performed first, so their techniques were not yet refined. Analgesic (painkiller)! Chem. RELATED WORK: Synthesis of Aspirin Lab Report . 5 mL of stock soap solution is added to test tube B. If you need guidance, follow the steps in the Report Sheets. The time values for each reaction were averaged with the other class values and standard deviation was calculated. Patented by Bayer in 1893! Aspirin Recrystallization The crude product of acetylsalicylic acid crystals were placed in a 125 mL Erlenmeyer flask and diethyl ether, heated on a steam bath, was added drop-wise, while swirling, until all crystals had dissolved. The equilibrated thermometer was immediately placed into the reaction solution and the initial temperature on the thermometer was noted. Anti-inflammatory (inhibition of the synthesis of prostaglandins)! Aspirin Synthesis Tap water was heated on a steam bath in a 250 mL beaker. 1. Aspirin: some background! Preparation of Aspirin Lab Report. The Synthesis and. General mechanism for a basic catalyst (major pathway pictured), Figure 3. In this experiment aspirin, also known as acetylsalicylic acid, was synthesized … H 2 SO 4 (use a dropper, H 2 SO 4 is highly corrosive) and swirl the flask gently until the salicylic acid dissolves. 8 August 2016. Aspirin has a long past. In this lab, for recrystallization, the solution was allowed to cool to room temperature very slowly, but was then plunged rapidly into ice water. 0000001234 00000 n
Kristina Madore March 5, 2008 Title: The Synthesis, Purification, and Colorimetric Analysis of Aspirin Introduction: The purpose of this experiment was to synthesize a common, over-the-counter drug that is used daily by many people around the world as a pain killer, fever reducer, and blood thinning agent. Introduction: The purpose of this experiment was to make aspirin via esterification, and to determine the percent yield we as a lab group made. ... Aspirin: Biological activity! Purpose: To determine which of four catalysts yields the fastest reaction rate in the acetylation of salicylic acid (1) to form acetylsalicylic acid (2). The definition of rate of reaction is the change in concentration of products over the change in time (∆[P] / ∆t). All the content of this paper is just her opinion on Synthesis of Aspirin Lab Report and should not be seen as the way of presenting the arguments. The temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water. The Synthesis and Analysis of Aspirin. The general mechanism for catalysation by a base, like the acetate ion or pyridine, is shown in Figure 2. The synthesis reaction is summarized below: Figure 1 Synthesis Reaction for Aspirin1. 0
Conclusion Synthesis Of Aspirin Lab Jennie K. Daniels Organic Chemistry 2121 11 February 2014 Synthesis of Aspirin Salicylic acid derivatives, or salicin, are found in the bark of the willow tree In the 5th century B.C., Hippocrates ground the bark into a powder, and later, the Natives Americans chewed on the bark to alleviate fever and pain1. Procedure: Week One: In order to synthesize aspirin, acetic acid was reacted with salicylic acid. Feb 2014; M El-Magbri; El-Magbri, M. (2014, February 26). Aspirin is a drug that is usually used to relieve minor aches and pain and other medical uses such as anti-inflammatory medication. Synthesis of Aspirin Aspirin is the single most manufactured drug in the world. The main objective of the synthesis of aspirin lab was so produce aspirin (acetylsalicylic acid) through the reaction of salicylic acid and acetic anhydride. Synthesis and analysis of aspirin formal lab report >>> next page Writing essay about my best friend The essay should not be written in the first person “i believe” or “i disagree” should be avoided in favor or straightforward objective analysis about the merits or. You will determine the percent yield of aspirin and you will confirm it's identity with FT-IR spectroscopic anaylsis. aspirin to diminish inflammation is due to its inhibition of the synthesis of prostaglandins. Formation of the N-acyliminium ion. The elapsed time was noted and recorded. Course Organic Chemistry (CHEM 2370 ) Academic year Aspirin, the ubiquitous pain reliever, goes by the chemical name acetylsalicylic acid. It is important to note, however, that the standard deviation of the sodium acetate – catalyzed reaction (31.0 s) is quite large and that the personal value is only just inside one standard deviation. The temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water. 0000003208 00000 n
... Aspirin: Biological activity! The contents of each tube and 50 mL distilled water were then added to a 125 mL Erlenmeyer flask. Analysis of Aspirin Lab Report - Free download as PDF File (.pdf), Text File (.txt) or read online for free. → H 3 PO 4 The crystals were rinsed with a small amount of iced tap water and dried. Starch is present in aspiring tablets to bind the medicine together. Anti-inflammatory (inhibition of the synthesis of prostaglandins)! Put the plate onto its hottest setting, once the water is boiling reduce the setting & using a thermometer maintain a temperature of around 100 0. temperature tap water. Thus, unknown compound B was determined to be impure acetylsalicylic acid. Compounds B and C both experienced a color change, though B experienced a stronger one, so it was not possible to distinguish them using the ferric chloride test alone. The Synthesis and Analysis of Aspirin. 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